National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
End of
Translation
Translation
AHRQ Research Studies Date
Topics
- Access to Care (3)
- Adverse Drug Events (ADE) (48)
- Adverse Events (140)
- Alcohol Use (2)
- Ambulatory Care and Surgery (9)
- Antibiotics (14)
- Antimicrobial Stewardship (4)
- Anxiety (1)
- Arthritis (16)
- Asthma (8)
- Back Health and Pain (1)
- Behavioral Health (31)
- Blood Clots (19)
- Blood Pressure (13)
- Blood Thinners (11)
- Brain Injury (7)
- Cancer (68)
- Cancer: Breast Cancer (19)
- Cancer: Cervical Cancer (1)
- Cancer: Colorectal Cancer (8)
- Cancer: Lung Cancer (4)
- Cancer: Ovarian Cancer (2)
- Cancer: Prostate Cancer (5)
- Cardiovascular Conditions (125)
- Caregiving (3)
- Care Management (4)
- Case Study (10)
- Catheter-Associated Urinary Tract Infection (CAUTI) (2)
- Centers for Education and Research on Therapeutics (CERTs) (2)
- Central Line-Associated Bloodstream Infections (CLABSI) (7)
- Children/Adolescents (75)
- Chronic Conditions (36)
- Clinical Decision Support (CDS) (12)
- Clinician-Patient Communication (6)
- Clostridium difficile Infections (8)
- Colonoscopy (5)
- Communication (7)
- Community-Acquired Infections (11)
- Community-Based Practice (2)
- Comparative Effectiveness (23)
- Complementary and Alternative Medicine (1)
- COVID-19 (23)
- Critical Care (7)
- Cultural Competence (1)
- Data (4)
- Dementia (7)
- Dental and Oral Health (1)
- Depression (20)
- Diabetes (41)
- Diagnostic Safety and Quality (21)
- Dialysis (2)
- Digestive Disease and Health (12)
- Disparities (17)
- Domestic Violence (2)
- Education (1)
- Education: Continuing Medical Education (1)
- Education: Patient and Caregiver (9)
- Elderly (81)
- Electronic Health Records (EHRs) (32)
- Electronic Prescribing (E-Prescribing) (2)
- Emergency Department (34)
- Emergency Medical Services (EMS) (4)
- Emergency Preparedness (1)
- Evidence-Based Practice (33)
- Eye Disease and Health (5)
- Falls (24)
- Family Health and History (7)
- Genetics (11)
- Guidelines (9)
- Healthcare-Associated Infections (HAIs) (50)
- Healthcare Cost and Utilization Project (HCUP) (29)
- Healthcare Costs (10)
- Healthcare Delivery (3)
- Healthcare Utilization (9)
- Health Information Technology (HIT) (40)
- Health Insurance (3)
- Health Literacy (3)
- Health Promotion (3)
- Health Services Research (HSR) (2)
- Health Status (10)
- Health Systems (4)
- Heart Disease and Health (73)
- Hepatitis (5)
- Home Healthcare (10)
- Hospital Discharge (13)
- Hospitalization (54)
- Hospital Readmissions (47)
- Hospitals (27)
- Human Immunodeficiency Virus (HIV) (25)
- Imaging (7)
- Implementation (4)
- Infectious Diseases (20)
- Influenza (1)
- Injuries and Wounds (42)
- Inpatient Care (5)
- Intensive Care Unit (ICU) (11)
- Kidney Disease and Health (21)
- Labor and Delivery (15)
- Learning Health Systems (1)
- Lifestyle Changes (16)
- Long-Term Care (9)
- Low-Income (4)
- Maternal Care (9)
- Medicaid (6)
- Medical Devices (4)
- Medical Errors (10)
- Medical Expenditure Panel Survey (MEPS) (6)
- Medical Liability (3)
- Medicare (11)
- Medication (111)
- Medication: Safety (20)
- Men's Health (4)
- Methicillin-Resistant Staphylococcus aureus (MRSA) (6)
- Mortality (61)
- Neonatal Intensive Care Unit (NICU) (2)
- Neurological Disorders (17)
- Newborns/Infants (23)
- Nursing (3)
- Nursing Homes (14)
- Nutrition (11)
- Obesity (27)
- Obesity: Weight Management (5)
- Opioids (15)
- Organizational Change (1)
- Orthopedics (6)
- Osteoporosis (5)
- Outcomes (59)
- Pain (3)
- Palliative Care (3)
- Patient-Centered Healthcare (8)
- Patient-Centered Outcomes Research (54)
- Patient Adherence/Compliance (2)
- Patient and Family Engagement (1)
- Patient Safety (100)
- Patient Self-Management (1)
- Payment (2)
- Pneumonia (6)
- Policy (4)
- Practice Patterns (5)
- Pregnancy (29)
- Prevention (52)
- Primary Care (13)
- Provider (6)
- Provider: Clinician (2)
- Provider: Health Personnel (2)
- Provider: Nurse (3)
- Provider: Pharmacist (2)
- Provider Performance (3)
- Public Health (11)
- Quality Improvement (12)
- Quality Indicators (QIs) (4)
- Quality Measures (4)
- Quality of Care (17)
- Quality of Life (3)
- Racial and Ethnic Minorities (44)
- Registries (9)
- Rehabilitation (2)
- Research Methodologies (10)
- Respiratory Conditions (32)
- (-) Risk (759)
- Rural Health (3)
- Screening (19)
- Sepsis (16)
- Sex Factors (6)
- Sexual Health (9)
- Shared Decision Making (24)
- Skin Conditions (11)
- Sleep Problems (6)
- Social Determinants of Health (33)
- Social Media (2)
- Stress (4)
- Stroke (27)
- Substance Abuse (16)
- Surgery (120)
- Telehealth (1)
- Tobacco Use (9)
- Tools & Toolkits (3)
- Transitions of Care (5)
- Transplantation (14)
- Trauma (11)
- Treatments (5)
- U.S. Preventive Services Task Force (USPSTF) (19)
- Uninsured (1)
- Urban Health (8)
- Urinary Tract Infection (UTI) (3)
- Vaccination (4)
- Vulnerable Populations (5)
- Web-Based (1)
- Women (45)
- Workforce (1)
- Young Adults (9)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 759 Research Studies DisplayedKostick-Quenet KM, Lang B, Dorfman N
Patients' and physicians' beliefs and attitudes towards integrating personalized risk estimates into patient education about left ventricular assist device therapy.
This study explored stakeholder attitudes toward the utility, acceptability, usefulness, and best practices for integrating personalized risk (PR) estimates into patient education and decision making about Left Ventricular Assist Device (LVAD). This was a 5-year multi-institutional AHRQ project where the authors conducted 40 interviews with stakeholders (physicians, nurse coordinators, patients, and caregivers) and analyzed using Thematic Content Analysis. All stakeholder groups voiced positive views towards PR integration in decision making. Physicians felt PR can improve their decision making by enhancing insight into outcomes, enhance tailored pre-emptive care, increase confidence in decisions, and reduce bias and subjectivity. All stakeholder groups raised concerns about accuracy, representativeness and relevance of algorithms; predictive uncertainty; utility in relation to physician's expertise; potential negative reactions among patients; and overreliance.
AHRQ-funded; HS027784.
Citation: Kostick-Quenet KM, Lang B, Dorfman N .
Patients' and physicians' beliefs and attitudes towards integrating personalized risk estimates into patient education about left ventricular assist device therapy.
Patient Educ Couns 2024 May; 122:108157. doi: 10.1016/j.pec.2024.108157.
Keywords: Education: Patient and Caregiver, Risk, Cardiovascular Conditions
Neerland C, Slaughter-Acey J, Behrens K
An evidence map for social and structural determinants for maternal morbidity and mortality: a systematic review.
The study aimed to identify social and structural determinants of maternal morbidity and mortality during prenatal and postpartum periods in the U.S. Out of 8,378 references screened, 118 studies were included, covering domains like identity, socioeconomic factors, violence, and trauma. Findings revealed mixed patterns between risk factors and outcomes, with notable attention to depression and mental health. Advancing the field long-term should involve developing comprehensive datasets to thoroughly investigate intersections with biological and medical risk factors.
AHRQ-funded; 75Q80120D00008.
Citation: Neerland C, Slaughter-Acey J, Behrens K .
An evidence map for social and structural determinants for maternal morbidity and mortality: a systematic review.
Obstet Gynecol 2024 Mar; 143(3):383-92. doi: 10.1097/aog.0000000000005489.
Keywords: Social Determinants of Health, Maternal Care, Mortality, Evidence-Based Practice, Risk, Women, Outcomes
Ashburn NP, McCord JK, Snavely AC
Navigating the observation zone: do risk scores help stratify patients with indeterminate high-sensitivity cardiac troponins?
In this research letter the authors described their secondary analysis of the High-Sensitivity Cardiac Troponin I Assays in the United States (HIGH-US) study; their purpose was to assess the best way to evaluate observation zone patients who did not have an ischemic ECG. Their primary finding was that risk scores were unlikely to identify a subset of observation zone patients for early discharge without further monitoring, additional troponin measures, and stress testing or coronary angiography.
AHRQ-funded; HS029017.
Citation: Ashburn NP, McCord JK, Snavely AC .
Navigating the observation zone: do risk scores help stratify patients with indeterminate high-sensitivity cardiac troponins?
Circulation 2024 Jan 2; 149(1):70-72. doi: 10.1161/circulationaha.123.065030..
Keywords: Cardiovascular Conditions, Risk
Engelberg RS, Scheidell JD, Islam N
Associations between incarceration history and risk of hypertension and hyperglycemia: consideration of differences among Black, Hispanic, Asian and White Subgroups.
This study’s objective was to assess racial/ethnic group differences in the association between incarceration and hypertension and hyperglycemia. The authors performed a secondary data analysis using the National Longitudinal Survey of Adolescent to Adult Health (Add Health). They used Poisson regression to estimate the associations between lifetime history of incarceration reported during early adulthood with hypertension and hyperglycemia outcomes measured in mid-adulthood, including incident diagnosis. They evaluated whether associations varied by self-reported race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, and Asian) with an analytic sample of 4,015 Add Health respondents. Outcome measures included hypertension, systolic blood pressure >130 mmHG, and hyperglycemia. There was no evidence of an association between incarceration and measured health outcomes among non-Hispanic Black and non-Hispanic White participants. Among Hispanic participants, incarceration was associated with hyperglycemia (Adjusted Risk Ratio (ARR): 2.1), but not with hypertension risk. Incarceration was associated with elevated systolic blood pressure (ARR: 3.1) and hypertension (ARR: 1.7) among Asian participants, but not with hyperglycemia risk. Incarceration was associated with incident hypertension (ARR 2.5) among Asian subgroups.
AHRQ-funded; HS026120.
Citation: Engelberg RS, Scheidell JD, Islam N .
Associations between incarceration history and risk of hypertension and hyperglycemia: consideration of differences among Black, Hispanic, Asian and White Subgroups.
J Gen Intern Med 2024 Jan; 39(1):5-12. doi: 10.1007/s11606-023-08327-9..
Keywords: Vulnerable Populations, Racial and Ethnic Minorities, Blood Pressure, Cardiovascular Conditions, Risk
Haimovich AD, Shah MN, Southerland LT
Automating risk stratification for geriatric syndromes in the emergency department.
This study discussed using automated risk stratification to implement screening programs for geriatric syndromes in the emergency department (ED). This method would reduce significant workloads at a time of record-breaking ED patient volumes, staff shortages, and hospital boarding crises. The authors defined the concept of automated risk stratification and screening using existing electronic health record (EHR) data. They discussed progress made in three potential use cases in the ED: falls, cognitive impairment, and end-of-life and palliative care; emphasizing the importance of linking automated screening with systems of healthcare delivery. They found that research progress and operational deployment vary by use case, ranging from deployed solutions in falls screening to algorithmic validation in cognitive impairment and end-of-life care, but should still be considered a potential solution.
AHRQ-funded; HS027735.
Citation: Haimovich AD, Shah MN, Southerland LT .
Automating risk stratification for geriatric syndromes in the emergency department.
J Am Geriatr Soc 2024 Jan; 72(1):258-67. doi: 10.1111/jgs.18594..
Keywords: Elderly, Emergency Department, Risk, Health Information Technology (HIT)
Oke I, Elze T, Miller JW
Surgical approach and reoperation risk in intermittent exotropia in the IRIS Registry.
This cohort study compared the 5-year reoperation rates for children with intermittent exotropia (IXT). Reoperation rates for children with IXT treated with horizontal muscle strabismus surgery using bilateral lateral rectus recession (BLR) vs unilateral lateral rectus recession with medial rectus resection (RR) were compared. The authors examined data obtained from the Intelligent Research in Sight (IRIS) Registry on 7482 children (age, <18 years) with IXT who underwent horizontal eye muscle strabismus surgery, excluding children undergoing initial surgeries involving 3 or more horizontal muscles, vertical muscles, or reoperations. Primary outcome was the adjusted cumulative incidence of repeat horizontal muscle surgery within 5 years after the initial surgery. BLR was performed more frequently than RR (85.3% vs 14.7%), especially in younger children. After data adjustment, the 5-year cumulative incidence of reoperation was 21.3%. The adjusted 5-year cumulative incidence of reoperation was higher for BLR than for RR. Unilateral lateral rectus recession with medial rectus resection was associated with a lower 5-year reoperation risk compared with BLR. Younger age at time of initial surgery was associated with a higher reoperation risk.
AHRQ-funded; HS000063.
Citation: Oke I, Elze T, Miller JW .
Surgical approach and reoperation risk in intermittent exotropia in the IRIS Registry.
JAMA Ophthalmol 2024 Jan; 142(1):48-52. doi: 10.1001/jamaophthalmol.2023.5288..
Keywords: Surgery, Risk
Ray M, Zhao S, Wang S
Improving hospital quality risk-adjustment models using interactions identified by hierarchical group lasso regularisation.
This study’s goal was to see if using hierarchical group lasso regularization (HGLR) improved hospital quality risk adjustment (RA) models. The authors analyzed patient discharge de-identified data from 14 State Inpatient Databases, AHRQ Healthcare Cost and Utilization Project, California Department of Health Care Access and Information, and New York State Department of Health. They used HGLR to identify first-order interactions in several AHRQ inpatient quality indicators (IQI) - IQI 09 (Pancreatic Resection Mortality Rate), IQI 11 (Abdominal Aortic Aneurysm Repair Mortality Rate), and Patient Safety Indicator 14 (Postoperative Wound Dehiscence Rate). These RA models were compared with stratum-specific and composite main effects models with covariates selected by least absolute shrinkage and selection operator (LASSO). HGLR identified clinical meaning interactions for all models, with model performance similar or superior for composite models with HGLR-selected features, compared to those with LASSO-selected features. HGLR was found to be scalable to handle a large number of covariates and their interactions and is customizable to use multiple CPU cores to reduce analysis time.
AHRQ-funded; 290201200003I.
Citation: Ray M, Zhao S, Wang S .
Improving hospital quality risk-adjustment models using interactions identified by hierarchical group lasso regularisation.
BMC Health Serv Res 2023 Dec 15; 23(1):1419. doi: 10.1186/s12913-023-10423-9..
Keywords: Quality of Care, Hospitals, Risk
Chase BA, Pocica S, Frigerio R
Mortality risk factors in newly diagnosed diabetic cardiac autonomic neuropathy.
To inform the design of interventions to reduce mortality in cardiac autonomic neuropathy (CAN) patients with diabetes, researchers explored genetic variants,
clinical attributes, and autonomic testing findings present to assess possible associations with increased mortality. They reviewed the electronic medical records of patients with advanced disease at the time when CAN was diagnosed. Some clinical characteristics, as well as sex, race, ethnicity, and incidence of type 1 or type 2 diabetes mellitus were found to be similar in both survivors and non-survivors; clinical and autonomic testing characteristics were often similarly advanced in survivors and non-survivors. The researchers concluded that their analysis provided context by estimating hazard ratios relative to when CAN is objectively diagnosed and indicated that not all risk factors confer equal mortality risk. Their findings may inform both the development of guidelines for prevention and the design of larger studies to evaluate CAN mortality risk factors.
clinical attributes, and autonomic testing findings present to assess possible associations with increased mortality. They reviewed the electronic medical records of patients with advanced disease at the time when CAN was diagnosed. Some clinical characteristics, as well as sex, race, ethnicity, and incidence of type 1 or type 2 diabetes mellitus were found to be similar in both survivors and non-survivors; clinical and autonomic testing characteristics were often similarly advanced in survivors and non-survivors. The researchers concluded that their analysis provided context by estimating hazard ratios relative to when CAN is objectively diagnosed and indicated that not all risk factors confer equal mortality risk. Their findings may inform both the development of guidelines for prevention and the design of larger studies to evaluate CAN mortality risk factors.
AHRQ-funded; HS024057.
Citation: Chase BA, Pocica S, Frigerio R .
Mortality risk factors in newly diagnosed diabetic cardiac autonomic neuropathy.
Clin Auton Res 2023 Dec; 33(6):903-07. doi: 10.1007/s10286-023-00975-5.
Keywords: Mortality, Risk, Diabetes
Song J, Min SH, Chae S
Uncovering hidden trends: identifying time trajectories in risk factors documented in clinical notes and predicting hospitalizations and emergency department visits during home health care.
The purpose of this study was to characterize risk factor patterns documented in home health care (HHC) clinical notes and explore their relationships with hospitalizations or emergency department (ED) visits. The researchers analyzed data for 73,350 episodes of care from one large HHC organization utilizing dynamic time warping and hierarchical clustering analysis to characterize the patterns of risk factors over time documented in clinical notes. The study found that six temporal clusters emerged, reflecting varying patterns in how risk factors were documented. Patients with a sharp increase in documented risk factors over time had a 3 times greater probability of hospitalization or ED visit than patients with no documented risk factors. The majority of risk factors were found in the physiological domain, and a minority were found in the environmental domain.
AHRQ-funded; HS027742.
Citation: Song J, Min SH, Chae S .
Uncovering hidden trends: identifying time trajectories in risk factors documented in clinical notes and predicting hospitalizations and emergency department visits during home health care.
J Am Med Inform Assoc 2023 Oct 19; 30(11):1801-10. doi: 10.1093/jamia/ocad101..
Keywords: Emergency Department, Hospitalization, Home Healthcare, Risk
Romijn AC, Rastogi V, Proaño-Zamudio JA
Early versus delayed thoracic endovascular aortic repair for blunt thoracic aortic injury: a propensity score-matched analysis.
This study examined the outcomes of ≤24 h) versus delayed (>24 h) thoracic endovascular aortic repair (TEVAR) for blunt thoracic aortic injury (BTAI), taking the aortic injury severity into consideration. Current trauma surgery guidelines recommend delayed TEVAR. Patients undergoing TEVAR for BTAI in the American College of Surgeons Trauma Quality Improvement Program between 2016 and 2019 were included and then stratified into early (≤24 h) or delayed (>24 h). The cohort looked at included 1339 patients, of whom 1054 (79%) underwent early TEVAR. Compared with the delayed group, the early group had significantly less severe head injuries (early vs delayed; 25% vs 32%), fewer early interventions for AAS grade 1 occurred, and AAS grade 3 aortic injuries often were intervened upon within 24 hours (grade 1: 28% vs 47%; grade 3: 49% vs 23%). Compared with the delayed group, the early group had significantly higher in-hospital mortality (8.8% vs 4.4%, relative risk: 2.2, 95% CI: 1.1-4.4), alongside a shorter length of hospital stay (5.0 vs 10 days), a shorter intensive care unit length of stay (4.0 vs 11 days) and fewer days on the ventilator (4.0 vs 6.5 days). Regardless of the higher risk of acute kidney injury in the delayed group (3.3% vs 7.7%), no other differences in in-hospital complications were observed between the early and delayed group.
AHRQ-funded; HS027285.
Citation: Romijn AC, Rastogi V, Proaño-Zamudio JA .
Early versus delayed thoracic endovascular aortic repair for blunt thoracic aortic injury: a propensity score-matched analysis.
Ann Surg 2023 Oct 1; 278(4):e848-e54. doi: 10.1097/sla.0000000000005817..
Keywords: Surgery, Cardiovascular Conditions, Risk, Outcomes
Herzig SJ, Anderson TS, Urman RD
Risk factors for opioid-related adverse drug events among older adults after hospitalization for major orthopedic procedures.
The purpose of this retrospective cohort study was to identify risk factors for opioid-related adverse drug events (ORADEs) after hospital discharge following orthopedic procedures. The participants of this study included a national sample of Medicare beneficiaries who underwent major orthopedic surgery during hospitalization in 2016 and had an opioid prescription filled within 2 days of discharge. The study found that among 30,514 hospitalizations with a major orthopedic procedure and an opioid claim, a potential ORADE requiring hospital revisit occurred in 2.5%. After adjustment for patient characteristics, prior opioid use, co-prescribed sedating medications, and opioid prescription characteristics were not related with ORADEs. Independent risk factors did include age of 80 years or older, female sex, and clinical conditions, including heart failure, respiratory illness, kidney disease, dementia/delirium, anxiety disorder, and musculoskeletal/nervous system injuries.
AHRQ-funded; HS026215.
Citation: Herzig SJ, Anderson TS, Urman RD .
Risk factors for opioid-related adverse drug events among older adults after hospitalization for major orthopedic procedures.
J Patient Saf 2023 Oct 1; 19(6):379-85. doi: 10.1097/pts.0000000000001144..
Keywords: Elderly, Opioids, Adverse Drug Events (ADE), Adverse Events, Hospitalization, Orthopedics, Surgery, Medication, Risk, Medication: Safety, Patient Safety
Evans NJ, Arakkal AT, Cavanaugh JE
The incidence, duration, risk factors, and age-based variation of missed opportunities to diagnose pertussis: a population-based cohort study.
This study’s objective was to estimate the incidence, duration and risk factors for diagnostic delays associated with pertussis. The authors used longitudinal retrospective insurance claims from the Marketscan Commercial Claims and Encounters, Medicare Supplemental (2001-2020), and Multi-State Medicaid (2014-2018) databases. They estimated the number of visits with pertussis-related symptoms before diagnosis beyond that expected in the absence of diagnostic delays, including the number of visits representing a delay, the number of missed diagnostic opportunities per patient, and the duration of delays. They identified 20,828 patients meeting inclusion criteria. On average, delay duration was 12 days, and patients had almost 2 missed opportunities prior to diagnosis. The duration of delays increased considerably with age from an average of 5.6 days for patients aged less than 2 years to 13.8 days for patients aged ≥18 years. Factors associated with increased risk of delays included recent prescriptions for antibiotics not effective against pertussis, emergency department visits, and telehealth visits.
AHRQ-funded; HS027375.
Citation: Evans NJ, Arakkal AT, Cavanaugh JE .
The incidence, duration, risk factors, and age-based variation of missed opportunities to diagnose pertussis: a population-based cohort study.
Infect Control Hosp Epidemiol 2023 Oct; 44(10):1629-36. doi: 10.1017/ice.2023.31..
Keywords: Respiratory Conditions, Risk, Diagnostic Safety and Quality
Chae S, Davoudi A, Song J
Predicting emergency department visits and hospitalizations for patients with heart failure in home healthcare using a time series risk model.
This study’s objective was to develop a time series risk model for predicting emergency department (ED) visits and hospitalizations in patients with heart failure (HF) using longitudinal electronic health record data. The authors explored which data sources yield the best-performing models over various time windows. They used data collected from 9362 patients from a large home healthcare (HHC) agency and iteratively developed risk models using both structured and unstructured data. They developed seven specific sets of variables including: (1) the Outcome and Assessment Information Set, (2) vital signs, (3) visit characteristics, (4) rule-based natural language processing-derived variables, (5) term frequency-inverse document frequency variables, (6) Bio-Clinical Bidirectional Encoder Representations from Transformers variables, and (7) topic modeling. Risk models for 18 time windows (1-15, 45, and 60 days) before an ED visit or hospitalization were developed. They compared risk prediction performances using recall, precision, accuracy, F1, and area under the receiver operating curve (AUC). The best-performing model was built using a combination of all 7 sets of variables and the time window of 4 days before an ED visit or hospitalization.
AHRQ-funded; HS027742.
Citation: Chae S, Davoudi A, Song J .
Predicting emergency department visits and hospitalizations for patients with heart failure in home healthcare using a time series risk model.
J Am Med Inform Assoc 2023 Sep 25; 30(10):1622-33. doi: 10.1093/jamia/ocad129..
Keywords: Hospitalization, Emergency Department, Risk
Narindrarangkura P, Alafaireet PE, Khan U
Association rule mining of real-world data: uncovering links between race, glycemic control, lipid profiles, and suicide attempts in individuals with diabetes.
The objective of this study was to use the association rule mining (ARM) technique to identify a high-risk group of suicide attempts among patients with diabetes. Cerner Real-World Data™ was mined using this technique. The study results indicated that patients with diabetes who were never married and had average blood glucose levels below 150 mg/dl were more likely to attempt suicide, while patients aged 60 and older who had diabetes for less than five years were less likely to attempt suicide. The authors concluded that ARM showed the potential for knowledge discovery in large multi-center electronic health records data, and the results could be used by providers during outpatient clinic visits.
Citation: Narindrarangkura P, Alafaireet PE, Khan U .
Association rule mining of real-world data: uncovering links between race, glycemic control, lipid profiles, and suicide attempts in individuals with diabetes.
Inform Med Unlocked 2023; 42. doi: 10.1016/j.imu.2023.101345..
Keywords: Diabetes, Behavioral Health, Risk
Marcotte LM, Khor S, Flum DR
Factors associated with lung cancer risk factor documentation.
This cross-observational study’s objective was to identify factors associated with the minimum necessary information to determine an individual’s eligibility for lung cancer screening (ie, sufficient risk factor documentation) and to characterize clinic-level variability in documentation. The authors calculated the relative risk of sufficient lung cancer risk factor documentation by patient-, provider-, and system-level variables using Poisson regression models, clustering by clinic. They compared unadjusted, risk-adjusted, and reliability-adjusted proportions of patients with sufficient smoking documentation across 31 clinics using logistic regression models and 2-level hierarchical logit models to estimate reliability-adjusted proportions across clinics. A majority (60%) of 20,632 individuals were found to have sufficient risk factor documentation to determine screening eligibility. Patient-level factors were inversely associated with risk factor documentation including Black race, non-English preferred language, Medicaid insurance, and nonactivated patient portal, with documentation varying across clinics.
AHRQ-funded; HS026369.
Citation: Marcotte LM, Khor S, Flum DR .
Factors associated with lung cancer risk factor documentation.
Am J Manag Care 2023 Sep; 29(9):89354..
Keywords: Cancer: Lung Cancer, Cancer, Risk
Howell TC, Lumpkin S, Chaumont N
Predicting colorectal surgery readmission risk: a surgery-specific predictive model.
The purpose of this retrospective split-sample cohort study was to develop a predictive model for colorectal surgery patients for risk of 30-day readmission. The researchers included patients admitted to the colorectal surgery service who underwent surgery and were discharged from an academic tertiary hospital between 2017 and 2019. A total of 1549 patients met eligibility criteria. The study found the 30-day readmission rate of the cohort was 19.62%. Customized surgery-specific readmission models with comprehensive data sources outperformed the most utilized readmission indices in predicting 30-day readmission in colorectal surgery patients. The performance of the models were improved by utilizing more comprehensive datasets that include administrative and socioeconomic details about a patient and clinical information utilized for decision-making at the time of discharge.
AHRQ-funded; HS026363.
Citation: Howell TC, Lumpkin S, Chaumont N .
Predicting colorectal surgery readmission risk: a surgery-specific predictive model.
IISE Trans Healthc Syst Eng 2023; 13(3):175-81. doi: 10.1080/24725579.2023.2200210..
Keywords: Hospital Readmissions, Surgery, Risk
Sprague BL, Ichikawa L, Eavey J
Breast cancer risk characteristics of women undergoing whole-breast ultrasound screening versus mammography alone.
This study evaluated mammography screening failure risk among women undergoing supplemental ultrasound screening in clinical practice in comparison with women undergoing mammography alone. Screening ultrasounds and screening mammograms without supplemental screening were identified within three Breast Cancer Surveillance Consortium registries. A clinically significant proportion of women who had undergone mammography screening alone were at high mammography screening failure risk. Ultrasound screening was highly targeted to women with dense breasts, but only a small proportion were high mammography screening failure risk.
AHRQ-funded; HS018366.
Citation: Sprague BL, Ichikawa L, Eavey J .
Breast cancer risk characteristics of women undergoing whole-breast ultrasound screening versus mammography alone.
Cancer 2023 Aug 15; 129(16):2456-68. doi: 10.1002/cncr.34768..
Keywords: Cancer: Breast Cancer, Cancer, Women, Imaging, Screening, Risk
Rothberg MB, Haessler S, Deshpande A
Derivation and validation of a risk assessment model for drug-resistant pathogens in hospitalized patients with community-acquired pneumonia.
The purpose of this study was to develop and validate a model for risk of resistance to first-line community-acquired pneumonia (CAP) therapy. The study was conducted using data for adults hospitalized for CAP from 177 Premier Healthcare database hospitals and 11 Cleveland Clinic hospitals. The study found that among 138,762 eligible patients in the Premier database, 8.8% had positive cultures and 3.8% had organisms resistant to CAP therapy. The strongest predictor of resistance was infection with a resistant organism in the previous year. Markers of acute illness such as receipt of mechanical ventilation or vasopressors, and chronic illness such as pressure ulcer or paralysis were also related with resistant infections. The study model outperformed the Drug Resistance in Pneumonia (DRIP) model in the Premier holdout sample, the Cleveland Clinic hospitals sample. Clinicians at Premier facilities utilized broad-spectrum antibiotics for 20%-30% of their patients. In discriminating between patients with and without resistant infections, physician judgment slightly outperformed the DRIP instrument but not the study model.
AHRQ-funded; HS024277.
Citation: Rothberg MB, Haessler S, Deshpande A .
Derivation and validation of a risk assessment model for drug-resistant pathogens in hospitalized patients with community-acquired pneumonia.
Infect Control Hosp Epidemiol 2023 Jul; 44(7):1143-50. doi: 10.1017/ice.2022.229..
Keywords: Community-Acquired Infections, Pneumonia, Risk
Linfield GH, Patel S, Ko HJ
Evaluating the comparability of patient-level social risk data extracted from electronic health records: a systematic scoping review.
This study’s objective was to evaluate how and from where social risk data are extracted from electronic health records (EHRs) for research purposes, and how observed differences may impact study generalizability. A systematic scoping review was conducted of peer-reviewed literature that used patient-level EHR data to assess 1 ± 6 social risk domains: housing, transportation, food, utilities, safety, social support/isolation. The authors found 111 of 9022 identified articles met inclusion criteria. By domain, martial/partner status was most often included, predominantly defined by marital partner status, and extracted from structured sociodemographic data. Structured housing data was extracted most from billing codes and screening tools. Across domains, data were predominantly sourced from structured fields (n = 89/111) versus unstructured free text (n = 32/111).
AHRQ-funded; HS026383.
Citation: Linfield GH, Patel S, Ko HJ .
Evaluating the comparability of patient-level social risk data extracted from electronic health records: a systematic scoping review.
Health Informatics J 2023 Jul-Sep; 29(3):14604582231200300. doi: 10.1177/14604582231200300..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Social Determinants of Health, Risk
Kamineni M, Ötleş Meng E, Oh J
Prospective evaluation of data-driven models to predict daily risk of Clostridioides difficile infection at 2 large academic health centers.
The purpose of this prospective study was to assess a data-driven approach for Clostridioides difficile infection (CDI) risk prediction that had previously demonstrated a high performance in retrospective evaluations at 2 large academic health centers. The final retrospective cohort included 18,030 admissions (138 CDI cases) at Massachusetts General Hospital (MGH) and 25,341admissions (158 CDI cases) at Michigan Medicine. The prospective cohort included 13,712 admissions (119 CDI cases) at MGH and 26,864 admissions (190 CDI cases) at MM. At MGH, the model achieved area under the receiver operator characteristic curve (AUROC). AUROCs of 0.744 in the retrospective cohort and 0.748 in the prospective cohort. At MM, the model achieved AUROCs of 0.778 in the retrospective cohort and 0.767 in the prospective cohort. The AUROCs for predicting CDI risk on both retrospective and prospective cohorts were similar each month and did not exhibit significant monthly variation throughout either assessment period.
AHRQ-funded; HS027431.
Citation: Kamineni M, Ötleş Meng E, Oh J .
Prospective evaluation of data-driven models to predict daily risk of Clostridioides difficile infection at 2 large academic health centers.
Infect Control Hosp Epidemiol 2023 Jul; 44(7):1163-66. doi: 10.1017/ice.2022.218..
Keywords: Clostridium difficile Infections, Healthcare-Associated Infections (HAIs), Risk
Apathy NC, Dixit RA, Boxley CL
Variations in physician telemedicine provision.
This study’s objective was to quantify physician variation in telemedicine provisions and the extent to which telemedicine use is explainable by the individual physician, adjusting for temporal, patient, and visit factors. This cross-sectional study used data on adult primary care visits across MedStar Health, Stanford Health Care, and Intermountain Healthcare systems. Primary care physicians who conducted at least 1000 visits between March 13, 2020 and December 31, 2021 were included. Primary care visits were defined in the electronic health record and scheduling systems as completed outpatient visits with those included primary care physicians. The sample consisted of 2,410,471 visits total, with 25.6% via telemedicine seen by 729 physicians. Substantial variation in telemedicine provision was shown across physicians. At least 237 physicians (32.5%) had at least 1 high-outlier week of telemedicine provision. Patient demographics only accounted for 2.3% of the variation in telemedicine use, with the site accounting for 16.3% of the variation. Residual (unexplained) variation accounted for more than half of the explanations. Telemedicine use has slowly declined, largely due to the lack of physical examinations.
AHRQ-funded; HS028255.
Citation: Apathy NC, Dixit RA, Boxley CL .
Variations in physician telemedicine provision.
JAMA Netw Open 2023 Jul; 6(7):e2321955. doi: 10.1001/jamanetworkopen.2023.21955..
Keywords: Low-Income, Social Determinants of Health, Outcomes, Risk
O'Connor EA, Perdue LA, Coppola EL
Depression and suicide risk screening: updated evidence report and systematic review for the US Preventive Services Task Force.
The objectives of this article were to review the benefits and harms of depression and suicide risk screening and treatment and the accuracy of instruments to detect these conditions in primary care patients. Evidence gathered from the literature search supported screening for depression in primary care settings, including during pregnancy and postpartum. The authors noted, however, that there were numerous important gaps in the evidence for suicide risk screening.
AHRQ-funded; 290201500011I; 75Q80120D00004.
Citation: O'Connor EA, Perdue LA, Coppola EL .
Depression and suicide risk screening: updated evidence report and systematic review for the US Preventive Services Task Force.
JAMA 2023 Jun 20; 329(23):2068-85. doi: 10.1001/jama.2023.7787..
Keywords: U.S. Preventive Services Task Force (USPSTF), Screening, Depression, Behavioral Health, Evidence-Based Practice, Guidelines, Risk
Mahmud A, Cushing-Haugen K, Wellman R
Understanding the relationship between social risk factors and COVID-19 contacts.
The purpose of this study was to facilitate researchers’ understanding of the prevalence of patients' social risk factors during the pandemic and recognize how social risks may intensify COVID-19. Between January and September 2020, the researchers conducted a national survey of Kaiser Permanente members and analyzed only the data from those who responded to a set of COVID-19 survey items. The survey included questions on their experiences with social risks, whether they knew of people with COVID-19, if COVID-19 affected their emotional and mental health, and their preferred type of assistance. The study found that 62% of respondents reported social risks, with 38% reporting having 2 or more social risks. The most common response was financial strain (45%). One third of respondents reported one or more contact types with COVID-19. respondents with 2 or more COVID-19 contact types reported higher rates of housing instability, financial strain, food insecurity, and social isolation than those with fewer contacts. Fifty percent of respondents reported that COVID-19 affected their emotional, mental health negatively, and 19% of respondents noted that it affected their ability to maintain a job.
AHRQ-funded; HS013853.
Citation: Mahmud A, Cushing-Haugen K, Wellman R .
Understanding the relationship between social risk factors and COVID-19 contacts.
Perm J 2023 Jun 15; 27(2):18-22. doi: 10.7812/tpp/22.146..
Keywords: COVID-19, Risk, Public Health, Infectious Diseases
Ruderman SA, Nance RM, Drumright LN
Development of Frail RISC-HIV: a risk score for predicting frailty risk in the short-term for care of people with HIV.
The authors developed RISC-HIV, a frailty prediction risk score for HIV clinical decision-making. They predicted frailty risk among people with HIV (PWH) at seven US HIV clinics and followed for up to 2 years to identify short-term predictors of becoming frail. They concluded that RISC-HIV is a simple, easily implemented tool to assist in classifying PWH at risk for frailty in clinics.
AHRQ-funded; HS026154.
Citation: Ruderman SA, Nance RM, Drumright LN .
Development of Frail RISC-HIV: a risk score for predicting frailty risk in the short-term for care of people with HIV.
AIDS 2023 May 1; 37(6):967-75. doi: 10.1097/qad.0000000000003501..
Keywords: Human Immunodeficiency Virus (HIV), Risk
Lowry KP, Ichikawa L, Hubbard RA
Variation in second breast cancer risk after primary invasive cancer by time since primary cancer diagnosis and estrogen receptor status.
This study examined the timing of second breast cancers by primary cancer estrogen receptor (ER) status in the Breast Cancer Surveillance Consortium. The cohort studied included women who were diagnosed with American Joint Commission on Cancer stage I-III breast cancer identified within six Breast Cancer Surveillance Consortium registries from 2000 to 2017. Characteristics collected during primary breast cancer diagnosis included demographics, ER status, and treatment. Second breast cancer events included subsequent ipsilateral or contralateral breast cancers diagnosed >6 months after primary diagnosis. Cumulative incidence and second breast cancer rates by primary cancer ER status during 1-5 versus 6-10 years after diagnosis was examined. At 10 years, the cumulative second breast cancer incidence was 11.8% for women with ER-negative disease and 7.5% for those with ER-positive disease. Women with ER-negative cancer had higher second breast cancer rates than those with ER-positive cancer during the first 5 years of follow-up. After 5 years, second breast cancer rates were similar for women with ER-negative versus ER-positive breast cancer.
AHRQ-funded; HS018366.
Citation: Lowry KP, Ichikawa L, Hubbard RA .
Variation in second breast cancer risk after primary invasive cancer by time since primary cancer diagnosis and estrogen receptor status.
Cancer 2023 Apr 15;129(8):1173-82. doi: 10.1002/cncr.34679.
Keywords: Cancer: Breast Cancer, Cancer, Women, Risk