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The resolution service at https://doi.org resolves DOIs. You have attempted to resolve lookup/doi/10.1101/2021.04.26.21256110, which is not a DOI.

lookup/doi/10.1101/2021.04.26.21256110 may be a Handle (DOIs are a special sort of Handle). If lookup/doi/10.1101/2021.04.26.21256110 is a valid Handle you should be able to resolve it at https://hdl.handle.net.

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